Studies on Hemoglobin

Studies on the Fetal Hemoglobin of Rabbits.

Since KORBER1) discovered in 1865 that human fetal hemoglobin is more resistant to alkali than the adult one, numerous works indicating differences in properties of the fetal and the adult pigment have been published . Biochemically, a considerable dissimilarity is found in their amino acid compositions and primary structures, i. e. amino acid sequences2). Physiologically , it has long been kno...

Studies on Hemoglobin Biosynthesis: Asynchronous Synthesis of Hemoglobin a and Hemoglobin A2 by Erythrocyte Precursors.

Studies on hemoglobin metabolism. II. Pathways of hemoglobin iron metabolism in normal man.

It has been suggested by earlier work (1, 2) and especially by a recent paper by Finch (3), that when isotopically labeled iron is administered to the body the time required for complete isotopic equilibrium to be reached is very long, a matter of years. It is well established that labeled iron bound to transferrin is found almost entirely in the red cells two to three weeks after injection. Th...

Further studies on hemoglobin C. I. A description of three additional families segregating for hemoglobin C and sickle cell hemoglobin.

Hemoglobin C and Sickle Cell Hemoglobin By JAIEs V. NEEL, NI.I)., PH.D., EUGENE KAPLAN, M.1),, AND WOLF W. ZUELZER, M.D. I x PREVIOUS COMMUNICATIONS the biochemical, geusetic, ansd (‘linsical aspects of a newly recognsized insherited abnormality of Isemogiohins were briefly descu ibed.n , 2 isew’ hemoglohius, which s ’as insdependenstly desigusated hemoglobins-Ill by Kaplats, Zuelzet’, ansd Xee...

Studies on hemoglobin from the hagfish Epatatretus burgeri.

Ultracentrifugation studies on hemolysates from the erythrocytes of the hagfish, Eptatretus burgeri, showed that in dilute solution oxygenated hemoglobins were in a monomeric form with a molecular weight of approximately 18,000. In deoxygenated hemolysates or in concentrated solutions of oxygenated hemolysates, an aggregate product appeared which was considered to be a tetramer, as judged from ...